Charles River Portfolio of Products and Services

Beginning with the earliest use of research models in discovery and continuing across the development pipeline through proof-of-concept, Charles River supports customers’ efforts to discover new therapies for improved human health. From our commitment to ensuring continuous global availability of standardized animal models, to the expert design and conduct of safety and efficacy studies, we are focused on providing customers exactly what they need to deliver new therapeutics to patients who need them, as fast as possible and with uncompromising quality. With multiple locations around the world and capabilities spanning each phase of the drug development continuum, Charles River is the ideal partner for moving your product from animal to man in a rational, cost-effective, and timely manner.Click here to view our full portfolio of products and support services.

Basic Research
Charles River produces a variety of research model strains, including disease-specific and preconditioned models, for basic research and beyond. With more than six decades of experience, we have developed unmatched expertise in veterinary medicine and science. Our diagnostic testing and genetic monitoring services allow our customers to have the confidence that they are working with the exact models they need for their program. Our portfolio has also expanded to encompass not only the breeding and welfare of research models, but all of the scientific services, consulting, and staffing needs required to support quality in vivo research programs. To learn more, click Basic Research at criver.com.

In Vivo Discovery
Charles River provides discovery services that help customers screen, rank, and identify lead compounds that have the greatest potential for development in an efficient, accurate, and reliable manner. With extensive research model, pharmacology, and toxicology experience, Charles River serves as an extension of our customers' internal resources to develop customized programs. To learn more, click Discovery at criver.com.

Safety and Efficacy
Charles River offers a full range of in vivo and in vitro safety and efficacy testing services that comply with global regulatory guidelines. Our scientific, program management, and regulatory expertise help our customers cost-effectively produce evidence of a compound's biological activity and safety before moving to the clinical phase. Our customers also have access to our high-quality research models and related services, process manufacturing support, and laboratory services, as well as scientific consultants and regulatory advisors who can help interpret preclinical data and assist in the design of initial-stage clinical protocols. To learn more, click Safety Assessment at criver.com.

Clinical
Charles River conducts Phase I studies and also provides both early- and late-phase clinical support services. With our experience in both routine and procedurally intensive studies, we can conduct well-designed clinical safety programs and offer expert oversight to correlate and verify preclinical findings. Our clinicians can assist in determining a drug's pharmacologic action, metabolism, side effects, as well as its overall clinical safety through a wide range of clinical study types. As clinical trials begin, further in vitro and in vivo nonclinical studies performed within our global network of facilities provide additional information to support continuation of clinical trials.

With 250 beds, we have the resources to conduct Phase I clinical trials, including complex first-in-human trials. As clinical trials move to Phase II, III, and IV, Charles River offers a wide range of support services, specialty toxicology programs, process manufacturing testing, and regulatory advisory personnel to bring new chemical compounds into the marketplace. To learn more, click Early-Phase Clinical and Late-Phase Clinical Trials Support at criver.com.

Click here to learn more about our clinical capabilities.

Process Manufacturing
Charles River provides consulting services for the optimization of the product manufacturing process, starting from the small amount synthesized at the laboratory bench to large-scale manufacturing. We help our customers establish the physiochemical properties of a compound, best production practices, and process controls needed to efficiently and cost-effectively bring a compound to market. To learn more, click Process Manufacturing Support at criver.com.

To learn more about how our products and services can help you achieve your research goals faster, visit
booth 100-101 at any time during the meeting.